The Science of Psychedelics
Activate serotonin (5-HT) 2A receptors on cortical neurons Produce a profoundly altered conscious state Mystical experiences, awe & sense of connectedness
Structure Of LSD (Pink) Bound To Human 5-HT2A Receptor (Gold)
Increased Neural Functional Connectivity
Cortical Dendritogenesis
Markers of an Ideal Psychedelic Drug Candidate:
Half-life (minutes)
Drug
Half-life (minutes)
LSD
>145 (2.6 h in humans)
WP00314
49
WP00336
46
WP00307
13
WP00361
8